BIOS 284: Performing Quantitative Bottom-Up Chemoproteomics: From Theory to Real World Application

Course Description

Chemoproteomic techniques provide unparalleled insight into proteomes for deconvoluting targets and mechanisms of small molecules, yet performing high quality experiments remains challenging. This mini-course seeks to demystify these challenges to provide students the knowledge and tools to utilize chemoproteomics in their current and/or future research projects from experimental design through sample preparation. This course will implement didactic lectures to explain the underlying fundamental theory, workshops to perform statistical analysis in R of real world data, student-led journal club style discussions of key scientific papers, and a laboratory exercise to handle real experimental samples.